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Id: 27234 Autor: Fokkens, Wytske J; Trenite, Gijs J. Nolst; Virmond, Marcus; KleinJan, Alex; Andrade, Vera L. G; Baar, Nino G. van; Naafs, Ben. Título: The nose in leprosy: Immunohistology of the nasal mucosa. Fonte: Int. J. Lepr;66(3):328-339, Sept. 1998. ilus, tab. Resumo: A detailed study of the nose was undertaken in 40 leprosy patients with different classifications of leprosy and different durations of disease at two hospitals in Brazil. This manuscript describes the immunohistochemical data on cellular infiltrates in the nasal biopsies of those patients. It was surprising that the damage to the whole depth of the nasal mucosa, epithelium and lamina propria was considerable, as was the case in the nasal mucosa which looked relatively normal during clinical inspection. The epithelium showed large holes which looked like very extended goblet cells. Very obvious was the lack of vasoconstriction after cocaine application, and the vessels also showed a lack of staining with factor VIII, possibly indicating a disruption of the endothelium. The number of neurofilaments was extensively reduced in all leprosy groups compared to normal controls. As in the skin, an increased number of CD68+ cells was found in the lamina propria of the nasal mucosa of the lepromatous patients. Contrary to findings in the skin, in the nasal mucosa of the borderline/lepromatous patients the number of CD4+ cells was increased and the number of CD8+ cells was decreased compared to normal controls. The number of CD8+ cells tended to be more reduced when the history of leprosy was longer. It is not clear as yet whether the reduced numbers of CD8+ cells are acquired during infection or whether persons with a low number of CD8+ cells in the nose might have a higher risk of acquiring leprosy. (AU)^ien. Descritores: Hanseníase/imunol Hanseníase/patol Mucosa Nasal/imunol Mucosa Nasal/patol Meio Eletrônico: http://hansen.bvs.ilsl.br/textoc/revistas/intjlepr/1998/pdf/v66n3/v66n3a03.pdf - en. Localização: BR191.1

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Id: 27027 Autor: Ebenezer, Gigi J; Job, Anand; Abraham, Suneetha; Arunthathi, S; Rao, P. S. S. Sundar; Job, Charles K. Título: Nasal mucosa and skin of smear-positive leprosy patients after 24 months of fixed duration MDT: histopathological and microbiological study. Fonte: Int. J. Lepr;67(3):292-297, Sept., 1999. ilus, tab. Resumo: The skin and nasal mucosa of 10 lepromatous leprosy patients who had completed 24 doses of fixed duration multidrug therapy (MDT) but who continued to be skin-smear positive for acid-fast bacilli (AFB) were examined histopathologically. The nasal mucosa showed granuloma fractions that exceeded those seen in the skin specimens, signifying that activity in this region subsides much more gradually than the activity in the skin. Mouse foot pad studies done using T900r mice with an inoculum from the nasal mucosa biopsy specimens of these patients did not demonstrate any growth of Mycobacterium leprae, indicating that these bacilli were not viable. A skin specimen from one patient grew significant amounts of bacteria in the T900r mouse foot pad. These results show that 2 years of treatment with MDT would prevent dissemination of M. leprae from the nasal mucosa and, therefore, should preclude further transmission of the disease. It also indicates that viable bacteria might persist in the skin of patients, especially those with an initial bacterial index of > or = 4+ who have completed 24 doses of regular MDT. Therefore, a more cautious approach to administering only 12 doses of MDT to highly positive multibacillary patients is suggested. (AU)^ien. Descritores: Hanseníase/imunol Hanseníase/fisiopatol Hanseníase/microbiol Mucosa Nasal/patol Limites: Humanos Meio Eletrônico: http://hansen.bvs.ilsl.br/textoc/revistas/intjlepr/1999/pdf/v67n3/v67n3a09.pdf - en. Localização: BR191.1

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Id: 25524 Autor: Patrocinio, Lucas Gomes; Goulart, Isabela Maria Bernardes; Goulart, Luiz Ricardo; Patrocinio, Jose Antonio; Ferreira, Frederico Regerio; Fleury, Raul Negrao Título: Detection of Mycobacterium leprae in nasal mucosa biopsies by the polymerase chain reaction ..- Fonte: s.l; s.n; 2005. 6 p. ilus, tab. Resumo: Several discoveries about leprosy indicate that Mycobacterium leprae transmission mainly accurs by inhalation, and the nose is major port of entry and exit. The present study evaluated the clinical application of PCR for detection of M. leprae DNA in nasal mucosa biopsies in untreated leprosy patients (52) and their contacts (99) from the State Reference Center in Sanitary Dermatology and Leprosy, Uberlandia, MG, Brazil. PCR detection of a 372-base pair DNA fragment from M. leprae was accomplished in 36 (69.2%) patients, from which 34 (91.9%) of them were multibacillaries. Furhermore, PCR was positive in 3 (16.7%) of 18 slit-skin smear negative, 4 (25.0%) of 16 skin lesion BI negative, 8 (33.3%) of 24 nasal mucosa BI negative patients, and 10 of 99 contacts (10.1%). The presence of bacilli in 10.1% of the contats may potentially reflect an occult leprosy, and reflect an occult leprosy, and these patients must be accompanied, followed by a chemoprophylaxy treatment. Considering all PCR results against clinical and BI classification of patients and controls, we have found a sensitivity of 69.2%, a specificity of 89.9% and an accuracy of 82.8%. It has been demonstrated here through PCR of nasal biopsies that the bacillus invades the mucosa, passing through the nasal inferior turbinate to reach peripheral blood. Therefore, the molecular investigation of invasive nasal biopsies by PCR tests has proven to be useful in defining patients of higher risk of transmission and risk-group contacts, which is an important step ti reach the World Health Organization objective towards the elimination of leprosy as a public health problem (AU). Descritores: MUCOSA NASAL/imunol MUCOSA NASAL/les MUCOSA NASAL/microbiol MUCOSA NASAL/patol MYCOBACTERIUM LEPRAE/isol MYCOBACTERIUM LEPRAE/ultraest REACAO EM CADEIA DA POLIMERASE/estatíst REACAO EM CADEIA DA POLIMERASE/tend REACAO EM CADEIA DA POLIMERASE/util - BIOPSIA/estatíst  BIOPSIA/tend  BIOPSIA/util  HANSENIASE/clas  HANSENIASE/diag  HANSENIASE/microbiol  HANSENIASE/patol Limites: HUMANO Localização: BR191.a; 09307/s

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Id: 18512 Autor: Yassin, A; Shennawy, M. el; Enany G. el; Wassef, N. F; Shoeb, S Título: Leprosy of the upper respiratory tract. A clinical bacteriological, histopathological and histochemical study of twenty cases ..- Fonte: s.l; s.n; 1975. 7 p. ilus, tab. Resumo: Twenty cases clinically diagnosed as leprosy were thoroughly examined for E.N.T. lesions. These lesions were subjected to bacteriological, histopathological and histochemical studies. The results have been tabulated and discussed with special stress on some findings which are of help in diagnosing the disease. (AU). Descritores: EPITELIO/patol PARALISIA FACIAL/etiol HISTOCITOQUIMICA HANSENIASE/diag HANSENIASE/microbiol HANSENIASE/patol LARINGE/patol LINFOCITOS MYCOBACTERIUM LEPRAE/isol METAPLASIA/etiol MUCOSA NASAL/patol INFECCOES RESPIRATORIAS/microbiol INFECCOES RESPIRATORIAS/patol FARINGE/patol - RINITE ATROFICA/etiol  CELULAS PLASMATICAS Limites: HUMANO MASCULINO FEMININO CRIANÇA ADULTO MEIA-IDADE IDOSO ADOLESCENTE Meio Eletrônico: - . Localização: BR191.1. 9119/s

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Id: 18288 Autor: Barton, R. P. E Título: Importance of nasal lesions in early lepromatous leprosy ..- Fonte: s.l; s.n; dec. 1975. 4 p. mapas, tab. Resumo: There are some 20 million people in the world with leprosy. In the lepromatous form of the illness the nose becomes infected very early in the disease process. The nasal discharge which occurs is heavily bacillated and is the most potent source of exit of Mycobacterium leprae from the body. The necessity for early diagnosis and treatment of leprosy in the absence of an effective vaccine is discussed and the pathological changes that occur in the nose are outlined. The roles which the leprologist and the rhinologist are able to play are mentioned.(AU). Descritores: RIFAMPINA/uso terap DAPSONA/uso terap MYCOBACTERIUM LEPRAE/isol MUCOSA NASAL/patol MUCOSA NASAL/secr HANSENIASE/compl HANSENIASE/diag HANSENIASE/quimioter HANSENIASE/microbiol HANSENIASE/patol Limites: HUMANO Meio Eletrônico: - . Localização: BR191.1; 01398/s

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Id: 18281 Autor: Mehta, Lata; Kasbekar, V; Apte, N; Antia, N. H Título: Evolution of nasal mucosal lesions in leprosy (histological study) ..- Fonte: s.l; s.n; jan. 1981. 6 p. ilus, tab. Resumo: Four stages of nasal pathology in tuberculoid leprosy is described. In every atrophic rhinitis case nasal biopsy is advocated. Rhinoscopic examination should be done in family contacts and early cases of leprosy.(AU). Descritores: HANSENIASE/compl HANSENIASE/diag HANSENIASE/patol MUCOSA NASAL/patol RINITE ATROFICA/etiol RINITE ATROFICA/patol RINOSCLEROMA/etiol RINOSCLEROMA/patol BIOPSIA Limites: HUMANO Meio Eletrônico: - . Localização: BR191.1; 01391/s

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Id: 18244 Autor: Barton, R. P; Davey, T. F Título: Early leprosy of the nose and throat ..- Fonte: s.l; s.n; oct. 1976. 9 p. ilus, mapas, tab. Resumo: The E.N.T. Surgeon may be confrontede with various presentations of leprosy, which takes three main forms. Current patterns of migration mean that the disease may be encountered in any country and early diagnosis os of great importance to the patient for his future benefit and, with lepromatous leprosy, to the community to prevent dissemination of M. Leprae, the causative organism. The classification, clinical presentation and means of confirming the diagnosis are stated.(AU). Descritores: INDIA MUCOSA NASAL/microbiol MUCOSA NASAL/patol PALATO/patol DOENCAS NASAIS/diag HANSENIASE/diag HANSENIASE/microbiol HANSENIASE/patol MYCOBACTERIUM LEPRAE/isol DOENCAS FARINGEAS/diag Limites: HUMANO MASCULINO FEMININO Meio Eletrônico: - . Localização: BR191.1; 01455/s

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Id: 18160 Autor: Yassin, A; Shennawy M. el; Enany, G. el; Wassef, N. F; Shoeb, S Título: Leprosy of the upper respiratory tract ..- Fonte: s.l; s.n; may 1975. 7 p. ilus, tab. Resumo: Twenty cases clinically diagnosed as leprosy were thoroughly examined for E.N.T. lesions. These lesions were subjected to bacteriological, histopathological and histochemical studies. The results have been tabulated and discussed with special stress on some findings which are of help in diagnosing the disease.(AU). Descritores: HANSENIASE/diag HANSENIASE/microbiol HANSENIASE/patol METAPLASIA/etiol MYCOBACTERIUM LEPRAE/isol MUCOSA NASAL/patol INFECCOES RESPIRATORIAS/microbiol INFECCOES RESPIRATORIAS/patol RINITE ATROFICA/etiol Limites: HUMANO MASCULINO FEMININO CRIANÇA ADULTO MEIA-IDADE IDOSO ADOLESCENTE Meio Eletrônico: - . Localização: BR191.1; 01379/s

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Id: 18157 Autor: Barton, R. P. E; McDougall, A. C Título: The paranasal sinuses in lepromatous leprosy ..- Fonte: s.l; s.n; oct. 1979. 5 p. . Resumo: During the course of a larger study of patients with treated lepromatous leprosy attending a hospital in South India, sixteen patients with untreated disease presented with symptoms suggesting both intranasal and sinus involvement. Radiological abnormalities of the sinus were recorded in all sixteen patients and the results have been published separately. This paper describes the clinical and bacteriological findings, together with the results of histopathological examination of biopsies of sinus mucosa in two patients, in both of whom there was a histiocytic infiltrate, with acid-fast bacilli. In one of these biopsies, bacilli in the lamina propria were numerous; globi were common, and 20% of free-standing organisms were solid-staining. The significance of these findings is discussed with emphasis on the value of a full ear, nose and throat examination in all cases of leprosy, especially those with the lepromatous form. In this type of leprosy the upper respiratory tract tissues are clearly of importance for the lodgement and of multiplication of bacilli; it is possible that the paranasal air sinuses, with their large surface area, may contribute to the numbers of bacilli which are disseminated from the nose into the environment.(AU). Descritores: HANSENIASE/patol HANSENIASE/transm TEMPERATURA CORPORAL SEIO MAXILAR/anat SEIO MAXILAR/patol MUCOSA NASAL/patol SEPTO NASAL/microbiol SEIOS PARANASAIS/patol SEIOS PARANASAIS/radiogr Limites: HUMANO Meio Eletrônico: - . Localização: BR191.1; 01377/s

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Id: 17859 Autor: Chacko, C. J; Bhanu, T; Victor, V; Alexander, R; Taylor, P. M; Job, C. K Título: The significance of changes in the nasal mucosa in indeterminate, tuberculoid and borderline leprosy ..- Fonte: s.l; s.n; jan. 1979. 15 p. tab. Resumo: A study of nasal biopsies from 137 leprosy patients classified on the basis of clinical, microbiological and skin biopsy as Indeterminate, Tuberculoid, Borderline-tuberculoid and Borderline-leproma was undertaken. Changes suggestive of leprosy viz., nerve and smooth muscle inflammation with a few acid fast bacilli in a proportion of the biopsies were seen in all groups of patients examined. This suggests, that even in Indeterminate and Tuberculoid leprosy the disease becomes generalised by the time clinical manifestations appear in skin. Tuberculoid granuloma was seen in two nasal biopsies from Borderline-tuberculoid leprosy patients, one of which was located in the wall of a vein, suggesting the possibility of intravascular dissemination of the disease even in non-lepromatous leprosy. 33 of the patients were children 15 years and below and they also showed changes such as nerve and smooth muscle inflammation but bacilli were seen only in the Borderline group. These findings suggest involvement of the nasal mucosa early in the course of the disease as 70% of the children had the skin lesion for less than one year. The nasal mucosa offers favourable conditions for the growth of the organisms and is readily accessible to infection by droplets, and therefore, it could be one of the primary sites of involvement in leprosy.(AU). Descritores: BIOPSIA HANSENIASE/microbiol HANSENIASE/patol MYCOBACTERIUM LEPRAE/isol MUCOSA NASAL/microbiol MUCOSA NASAL/patol PELE/microbiol Limites: HUMANO MASCULINO FEMININO PRÉ-ESCOLAR CRIANÇA ADOLESCENTE Meio Eletrônico: - . Localização: BR191.1; 02144/s

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Id: 14305 Autor: Scollard, David M; Skinsnes, Olaf K Título: Oropharyngeal leprosy in art, history, and medicine ..- Fonte: s.l; s.n; 1999. 8 p. ilus. Descritores: OSSOS FACIAIS FACIES HISTORIA DA MEDICINA DO SÉCULO 15 HISTORIA DA MEDICINA DO SÉCULO 16 HISTORIA DA MEDICINA DO SÉCULO 17 HISTORIA DA MEDICINA DO SÉCULO 19 HISTORIA DA MEDICINA MEDIEVAL JAPAO HANSENIASE MEDICINA NA ARTE MUCOSA BUCAL MUCOSA NASAL EUROPA (CONTINENTE Localização: BR191.1; 07406/s

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Id: 14043 Autor: Soni, N. K Título: Microscopic rhinoscopy in lepromatous leprosy ..- Fonte: s.l; s.n; 1997. 3 p. tab. Descritores: CEPIALET HANSENIASE LEPROMATOSA ENDOSCOPIA MUCOSA NASAL DOENÇAS NASAIS Localização: BR191.1; 07009/s

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